ARWEN：一个用于检测后生动物线粒体核苷酸序列中tRNA基因的程序。
ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences.
作者信息
Laslett Dean, Canbäck Björn
机构信息
Murdoch University, Perth, Western Australia, Australia.
出版信息
Bioinformatics. 2008 Jan 15;24(2):172-5. doi: 10.1093/bioinformatics/btm573. Epub 2007 Nov 22.
MOTIVATION
Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.
RESULTS
In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100% of previously annotated genes.
AVAILABILITY
An online version, software for download and test results are available at www.acgt.se/online.html
动机
线粒体基因组编码自身的转运RNA（tRNA）。与它们细菌祖先中的tRNA相比，这些tRNA在序列和结构上往往存在简并性。这是当前tRNA基因预测程序在识别线粒体tRNA基因时表现不佳的原因之一。因此，需要一个专门用于预测这些tRNA的新程序。
结果
在本研究中，我们展示了软件ARWEN，它可识别后生动物线粒体核苷酸序列中的tRNA基因。ARWEN能检测到近100%的先前注释基因。
可用性
在线版本、可供下载的软件以及测试结果可在www.acgt.se/online.html获取。
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