Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
Hepatol Res. 2008 May;38(5):429-40. doi: 10.1111/j.1872-034X.2007.00303.x. Epub 2007 Nov 23.
Hepatic ischemia/reperfusion (I/R) results in a chain of events that culminate in liver dysfunction and injury. I/R injury is characterized by early oxidant stress followed by an intense acute inflammatory response that involves the transcription factor nuclear factor (NF)-kappaB. In addition to being a primary regulator of pro-inflammatory gene expression, NF-kappaB may play other roles in the hepatic response to I/R, such as mediating the expression of anti-apoptotic genes, preventing the accumulation of damaging reactive oxygen species, facilitating liver regeneration, and mediating the protective effects of ischemic preconditioning. In the present study, we review the diverse functions of NF-kappaB during hepatic I/R injury.
肝脏缺血/再灌注（I/R）会引发一系列事件，最终导致肝功能障碍和损伤。I/R 损伤的特征是早期氧化应激，随后是强烈的急性炎症反应，涉及转录因子核因子（NF）-kappaB。NF-kappaB 除了是促炎基因表达的主要调节剂外，在肝脏对 I/R 的反应中可能还具有其他作用，例如介导抗凋亡基因的表达，防止破坏性活性氧物质的积累，促进肝脏再生以及介导缺血预处理的保护作用。在本研究中，我们综述了 NF-kappaB 在肝脏 I/R 损伤过程中的多种功能。
