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2例感染人类免疫缺陷病毒患者的多发性发疹性皮肤纤维瘤

[Multiple eruptive dermatofibromas in 2 patients infected with the human immunodeficiency virus].

作者信息

García-Millán C, Aldanondo I, Fernández-Lorente M, Carrillo R, Jaén P

机构信息

Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

出版信息

Actas Dermosifiliogr. 2007 Dec;98(10):702-6.

Abstract

Multiple eruptive dermatofibromas are an uncommon clinical entity in which several lesions appear in a short period of time. Baraf and Shapiro defined them in 1970 as the appearance of at least 15 dermatofibromas in a few months. Given that incipient cases might be omitted, appearance of 5 to 8 dermatofibromas in 4 months has been proposed as sufficient to establish diagnosis. Although this entity has been reported in healthy subjects, it usually appears with underlying autoimmune diseases (lupus erythematosus), human immunodeficiency virus (HIV) infection, or treatment with certain drugs. We report 2 cases of multiple eruptive dermatofibromas associated with HIV infection. One of these patients was unaware of being infected with HIV, and so we believe that the appearance of these skin lesions could help early diagnosis of autoimmune diseases or patients with immunodepression.

摘要

多发性发疹性皮肤纤维瘤是一种不常见的临床病症,其中多个损害在短时间内出现。巴拉夫和夏皮罗在1970年将其定义为在几个月内出现至少15个皮肤纤维瘤。鉴于初期病例可能被遗漏,有人提出在4个月内出现5至8个皮肤纤维瘤就足以确诊。尽管该病症已在健康受试者中报道过,但它通常与潜在的自身免疫性疾病(红斑狼疮)、人类免疫缺陷病毒(HIV)感染或某些药物治疗有关。我们报告2例与HIV感染相关的多发性发疹性皮肤纤维瘤病例。其中1例患者未意识到自己感染了HIV,因此我们认为这些皮肤损害的出现有助于自身免疫性疾病或免疫抑制患者的早期诊断。

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