Antal A, Zelger B, Reifenberger J, Niehues T, Feyen O, Megahed M, Ruzicka T, Homey B
Department of Dermatology, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.
Br J Dermatol. 2007 Aug;157(2):382-5. doi: 10.1111/j.1365-2133.2007.08032.x. Epub 2007 Jun 26.
Multiple eruptive dermatofibromas are a rare presentation of dermatofibroma which are frequently associated with underlying diseases such as human immunodeficiency virus infection or lupus erythematosus. Eruptive dermatofibromas generally present a characteristic histology with a poorly circumscribed lesion showing hyperplasia of the epidermis, prominent bundles of collagen and a diffuse proliferation of fibrocytes. We report an unusual case of multiple eruptive dermatofibromas showing massive depositions of mucin within the dermis. A 20-year-old woman presented with nearly 100 red to yellowish papules and nodules distributed symmetrically all over the integument which developed over a period of 9 years. Comprehensive clinical and laboratory diagnostics showed no signs indicating any underlying disease. To our knowledge this is the first report of multiple eruptive myxoid dermatofibromas. We consider this case to be a unique presentation of multiple eruptive dermatofibroma showing massive deposition of mucin.
多发性发疹性皮肤纤维瘤是皮肤纤维瘤的一种罕见表现形式，常与潜在疾病相关，如人类免疫缺陷病毒感染或红斑狼疮。发疹性皮肤纤维瘤通常呈现出特征性的组织学表现，病变边界不清，显示表皮增生、明显的胶原束和纤维细胞的弥漫性增殖。我们报告了一例不寻常的多发性发疹性皮肤纤维瘤病例，其真皮内有大量黏蛋白沉积。一名20岁女性，在9年时间里全身对称分布着近100个红色至淡黄色丘疹和结节。全面的临床和实验室诊断未发现任何潜在疾病的迹象。据我们所知，这是首例多发性发疹性黏液样皮肤纤维瘤的报告。我们认为该病例是多发性发疹性皮肤纤维瘤的独特表现，伴有大量黏蛋白沉积。
