d'Arailh A-S, Michy T, Pioud R, Dravet F, Classe J-M
Service de chirurgie oncologique, centre régional de lutte contre le cancer René-Gauducheau, boulevard Jean-Monod, 44805 Saint Herblain, France.
Gynecol Obstet Fertil. 2007 Dec;35(12):1215-9. doi: 10.1016/j.gyobfe.2007.10.006. Epub 2007 Nov 26.
To elaborate a strategy of endometrial follow-up for premenopausal women treated with Tamoxifen as adjuvant hormonal treatment of breast cancer.
Retrospective study of 152 premenopausal patients treated with Tamoxifen in Nantes Comprehensive Cancer Center for a breast cancer from January 2003 to December 2005. Vaginal sonography was used in the follow-up of 70 of them.
Endometrial hypertrophy was found in 26 patients. Sonohysterography and hysteroscopy allowed to find 11 polyps and three hyperplasias in the 19 women who were investigated. In our study, endometrial pathology was found in 20% of premenopausal women treated with Tamoxifen (polyps or hyperplasia). Uterine bleeding was found in half patient of this group.
Vaginal sonography monitoring could be proposed to premenopausal women treated with Tamoxifen among whom endometrial pathology is usual.
制定一项针对接受他莫昔芬辅助激素治疗乳腺癌的绝经前女性的子宫内膜随访策略。
对2003年1月至2005年12月在南特综合癌症中心接受他莫昔芬治疗乳腺癌的152例绝经前患者进行回顾性研究。其中70例患者在随访中使用了阴道超声检查。
26例患者发现子宫内膜增厚。在接受检查的19名女性中，子宫超声造影和宫腔镜检查发现了11个息肉和3例增生。在我们的研究中，接受他莫昔芬治疗的绝经前女性中有20%发现了子宫内膜病变（息肉或增生）。该组中有一半患者出现子宫出血。
对于接受他莫昔芬治疗且子宫内膜病变较为常见的绝经前女性，可建议进行阴道超声监测。
