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[派立苏在慢性肾小球肾炎患者肾衰竭初期改善肾脏排泄功能的能力]

[The ability of partusisten to improve kidney excretory function in the initial stage of kidney failure in patients with chronic glomerulonephritis].

作者信息

Skipskiĭ I M, Komandenko M S, Shulutko B I, Zamoskovskaia G A

出版信息

Ter Arkh. 1991;63(12):125-7.

PMID:1803590
Abstract

To assess the effect of partusisten (fenoterol) on excretory function of the kidneys, the drug was administered per os in a dose of 10 mg/day for 7-10 days in 17 chronic glomerulonephritis patients with initial forms (stages I-IIA) of renal failure. A dramatic increase of glomerular filtration, a certain rise of tubular reabsorption, a reduction of blood concentration of nitrous residues were revealed, which was accompanied by electrolyte shifts and hemodynamic changes characteristic of partusisten. It is concluded that partusisten can be used as a drug ameliorating excretory function of the kidneys in chronic glomerulonephritis patients with initial forms of chronic renal failure.

摘要

为评估间羟舒喘宁(酚丙喘宁)对肾脏排泄功能的影响,对17例患有早期(Ⅰ-ⅡA期)肾功能衰竭的慢性肾小球肾炎患者口服该药,剂量为每日10毫克,持续7-10天。结果显示肾小球滤过率显著增加,肾小管重吸收有一定程度升高,血液中含氮代谢产物浓度降低,同时伴有间羟舒喘宁特有的电解质变化和血流动力学改变。结论是间羟舒喘宁可作为一种能改善患有早期慢性肾功能衰竭的慢性肾小球肾炎患者肾脏排泄功能的药物。

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