Keegan Brian R, Kamino Hideko, Fangman William, Shin Helen T, Orlow Seth J, Schaffer Julie V
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York City, New York 10016, USA.
Pediatr Dermatol. 2007 Nov-Dec;24(6):621-7. doi: 10.1111/j.1525-1470.2007.00550.x.
We describe two young children who developed relapsing, pruritic, papulovesicular eruptions in multiple bands along Blaschko lines on the neck, trunk, and extremities. Skin specimens in both revealed spongiotic dermatitis. This represents the first report of "blaschkitis" in children, providing further evidence that lichen striatus and blaschkitis are related acquired Blaschko-linear dermatoses that exist on a spectrum rather than as the childhood and adult form of a single disease entity. We highlight the features that differentiate blaschkitis from lichen striatus, review the potential roles of cutaneous mosaicism, environmental triggers, and background immunologic state in their pathogenesis, and discuss the spectrum of inflammatory dermatoses that can follow Blaschko lines.
我们描述了两名幼儿，他们在颈部、躯干和四肢沿布拉斯科线出现了多条复发性、瘙痒性丘疹水疱性皮疹带。两人的皮肤标本均显示为海绵状皮炎。这是儿童“布拉斯科线皮炎”的首例报告，进一步证明线状苔藓和布拉斯科线皮炎是相关的后天性沿布拉斯科线分布的皮肤病，它们存在于一个连续谱中，而非单一疾病实体的儿童和成人形式。我们强调了布拉斯科线皮炎与线状苔藓相鉴别的特征，回顾了皮肤镶嵌现象、环境触发因素和背景免疫状态在其发病机制中的潜在作用，并讨论了可沿布拉斯科线分布的炎症性皮肤病谱。
