Goode R L, Coursey D L
Laryngoscope. 1976 Jul;86(7):992-5. doi: 10.1288/00005537-197607000-00013.
A review of 1,192 student medical records shows a prior history of tonsillectomy in 41 percent of a control group and 22 percent of an infectious mononucleosis group--a significant difference (p less than 0.01). Nine hundred eighty-nine Stanford University students (421 females, 568 males) who visited Cowell Student Health Center between April and September, 1973, comprise the control group. Two hundred three students with positive monospot tests and clinical mononucleosis diagnosed between June, 1968, and May, 1973, comprise the experimental group. The lower incidence of tonsillectomy in the infectious mononucleosis group implies that the tonsillar lymphoid tissue serves as a reservoir and possible replicating milieu for the Epstein-Barr virus. Prior tonsillectomy may reduce the possibility of contracting infectious mononucleosis.
对1192份学生病历的回顾显示，对照组中有41%的学生有扁桃体切除术史，而传染性单核细胞增多症组中这一比例为22%——差异显著（p小于0.01）。1973年4月至9月间到考威尔学生健康中心就诊的989名斯坦福大学学生（421名女生，568名男生）组成了对照组。1968年6月至1973年5月间确诊为单核细胞增多症斑点试验呈阳性且患有临床传染性单核细胞增多症的203名学生组成了实验组。传染性单核细胞增多症组中扁桃体切除术的发生率较低，这意味着扁桃体淋巴组织是爱泼斯坦-巴尔病毒的储存库及可能的复制环境。既往扁桃体切除术可能会降低感染传染性单核细胞增多症的可能性。
