Sardesai Maya G, Moore Corey C
Department of Otolaryngology, St Joseph's Health Care, London, ON, Canada.
Otolaryngol Head Neck Surg. 2007 Dec;137(6):868-72. doi: 10.1016/j.otohns.2007.08.008.
To evaluate changes in dermal characteristics with subdermal fat grafting of cutaneous scars.
Prospective cohort.
Fourteen patients with various scar types were treated with subdermal fat grafting over 30 months. Dermal elasticity, vascularity, pigmentation, patient perception and satisfaction, and observer assessment of scar characteristics were evaluated preoperatively and 1 year after treatment with validated objective and subjective measures.
Significant improvements were observed in dermal elasticity, patient and observer perception of scar thickness, patient perception of stiffness, and observer perception of relief and pliability (P < 0.05). A trend toward significance was seen in observer assessment of height as evaluated by the Vancouver Scar Scale (P < 0.1). No significant differences were seen in quantitatively and qualitatively measured vascularity and pigmentation (P > 0.1). No significant difference in pain, pruritus, and irregularity were reported (P > 0.1).
Although fat grafting represents a subdermal process, it appears to improve certain quantitative and qualitative dermal characteristics. Fat grafting does not appear to affect skin color, vascularity, or patient symptoms.
评估皮下脂肪移植对皮肤瘢痕真皮特性的影响。
前瞻性队列研究。
14例不同瘢痕类型患者在30个月内接受皮下脂肪移植治疗。术前及治疗1年后,采用经过验证的客观和主观测量方法,评估真皮弹性、血管分布、色素沉着、患者感受及满意度,以及观察者对瘢痕特征的评估。
真皮弹性、患者及观察者对瘢痕厚度的感知、患者对硬度的感知、观察者对瘢痕减轻及柔韧性的感知均有显著改善(P < 0.05)。温哥华瘢痕量表评估观察者对瘢痕高度的评估有显著趋势(P < 0.1)。在定量和定性测量的血管分布及色素沉着方面未见显著差异(P > 0.1)。疼痛、瘙痒及瘢痕不规则性方面未见显著差异(P > 0.1)。
尽管脂肪移植是一个皮下过程,但似乎能改善某些定量和定性的真皮特性。脂肪移植似乎不影响皮肤颜色、血管分布或患者症状。