Small William, Mell Loren K, Anderson Penny, Creutzberg Carien, De Los Santos Jennifer, Gaffney David, Jhingran Anuja, Portelance Lorraine, Schefter Tracey, Iyer Revathy, Varia Mahesh, Winter Kathryn, Mundt Arno J
Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):428-34. doi: 10.1016/j.ijrobp.2007.09.042. Epub 2007 Nov 26.
To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy.
The Radiation Therapy Oncology Group led an international collaboration of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group, National Cancer Institute of Canada, European Society of Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTV and to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005.
The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph node regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, or endometrial cancer with cervical stromal invasion, it is also recommended that the CTV include the presacral lymph node region.
This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer.
制定子宫内膜癌和宫颈癌术后放疗临床靶区(CTV)定义图谱,用于盆腔调强放疗计划。
放射肿瘤学组牵头开展了一项由多个协作组参与的国际合作来制定该图谱。这些协作组包括放射肿瘤学组、妇科肿瘤学组、加拿大国家癌症研究所、欧洲放射治疗与肿瘤学会以及美国放射学会影像网络。通过问卷调查要求该组成员确定CTV应包含的区域,并在各自的计算机断层扫描图像上勾勒出这些区域。该组的初始制定工作始于2004年末,并在2005年6月召开的一次正式共识会议上达成最终成果。
委员会就子宫内膜癌和宫颈癌术后治疗的CTV定义达成了共识。CTV应包括髂总、髂外和髂内淋巴结区域。还应包括阴道上部3.0 cm以及阴道旁侧的阴道旁软组织。对于宫颈癌患者或伴有宫颈间质浸润的子宫内膜癌患者,建议CTV还应包括骶前淋巴结区域。
本报告为子宫内膜癌和宫颈癌术后调强放疗的CTV定义提供了国际模板。