Romanowska K, Kuduk-Jaworska J
Institute of Chemistry, Wrocław University.
Arch Immunol Ther Exp (Warsz). 1991;39(1-2):75-84.
A graph-theoretical method is applied to model of the relations between structure and biological activity of the anticancer Pt(II) complexes. Values of LD50, ID90, TI and % of ILS resulted from the treatment of animals bearing experimentalis ADJ/PC6 or L1210 tumors, available in the literature, were used as parameters characterizing the antitumor activity of platinum complexes. The results indicate that it is possible to find a topological description of these complexes which could be useful in their structure - activity investigations.
一种图论方法被应用于抗癌铂（II）配合物的结构与生物活性关系的建模。文献中提供的、来自动物实验性ADJ/PC6或L1210肿瘤治疗的半数致死剂量（LD50）、抑制率90%（ID90）、治疗指数（TI）和生命延长率（%ILS）值，被用作表征铂配合物抗肿瘤活性的参数。结果表明，有可能找到这些配合物的拓扑描述，这在它们的构效关系研究中可能是有用的。
