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Anthralin derivatives--inhibition of 5-lipoxygenase--antipsoriatic efficacy.

作者信息

Tanzer H, Braun C, Seidel M, Wiegrebe W

机构信息

Institute of Pharmacy, University, Regensburg, Germany.

出版信息

Arch Pharm (Weinheim). 1991 Nov;324(11):841-6. doi: 10.1002/ardp.2503241104.

DOI:10.1002/ardp.2503241104
PMID:1804060
Abstract

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no correlation between the "minimum structure" of Krebs and Schaltegger concerning antipsoriatic activity and the inhibitory effects against 5-lipoxygenase.

摘要

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