Fan Yongfeng, Yang Guo-Yuan
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, Room 3C-38, San Francisco, CA 94110, USA.
J Neuroimmune Pharmacol. 2007 Sep;2(3):284-9. doi: 10.1007/s11481-007-9073-3. Epub 2007 May 1.
In the normal mature brain, blood vessel formation is tightly downregulated. However, pathologic processes such as ischemia can induce cerebral vascular regeneration. Angiogenesis is one of the major styles of new vessel formation. In this article, we summarize the major angiogenic factors in the brain, discuss the significant changes of angiogenic factors and endothelial progenitor cells (EPCs) in response to brain ischemia, and finally, review the therapeutic potential of angiogenic factors and EPCs in experimental cerebral ischemia based on the concept of neurovascular unit.
在正常成熟大脑中，血管生成受到严格下调。然而，诸如缺血等病理过程可诱导脑血管再生。血管生成是新血管形成的主要方式之一。在本文中，我们总结了大脑中的主要血管生成因子，讨论了血管生成因子和内皮祖细胞（EPCs）在脑缺血反应中的显著变化，最后，基于神经血管单元的概念，综述了血管生成因子和EPCs在实验性脑缺血中的治疗潜力。
