Galetke W, Feier C, Muth T, Borsch-Galetke E, Rühle K-H, Randerath W
Krankenhaus Bethanien Solingen, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin, Universität Witten/Herdecke, Solingen.
Pneumologie. 2008 Feb;62(2):67-73. doi: 10.1055/s-2007-993033. Epub 2007 Nov 26.
Dynamic and static pulmonary compliance as well as the work of breathing are essential parameters for describing respiratory mechanics. However, current reference values or correlations with other pulmonary function variables have been established only in studies with small numbers of participants. Therefore, the aim of the present study was to compare pulmonary compliance and the work of breathing with different pulmonary function parameters in a large number of men.
In 208 healthy men, aged 20 to 70 years, spirometry, bodyplethysmography and carbon monoxide transfer factor measurements were conducted. The esophageal pressure method was used to measure dynamic (C (dyn)) and static (C (stat)) compliance.
C (dyn) and C (stat) were significantly correlated with total lung capacity (TLC), vital capacity (VC), forced expiratory volume in the first second (FEV (1)) and carbon monoxide transfer factor (T (LCO)). C (dyn) decreased with increasing age, while C (stat) was correlated with height. The elastic and non-elastic work of breathing were significantly correlated with airway resistance, but not with aging.
Lung volumes are important for the interpretation of pulmonary compliance and the work of breathing and therefore have to be considered in the assessment of respiratory mechanics. In contrast, the work of breathing is essentially influenced by the airway resistance. With increasing age there is only a small decrease in pulmonary compliance and the work of breathing.
动态和静态肺顺应性以及呼吸功是描述呼吸力学的重要参数。然而，目前的参考值或与其他肺功能变量的相关性仅在少数参与者的研究中得到确立。因此，本研究的目的是在大量男性中比较肺顺应性和呼吸功与不同肺功能参数的关系。
对208名年龄在20至70岁之间的健康男性进行了肺活量测定、体容积描记法和一氧化碳转运因子测量。采用食管压力法测量动态（C（dyn））和静态（C（stat））顺应性。
C（dyn）和C（stat）与肺总量（TLC）、肺活量（VC）、第1秒用力呼气量（FEV（1））和一氧化碳转运因子（T（LCO））显著相关。C（dyn）随年龄增长而降低，而C（stat）与身高相关。呼吸的弹性功和非弹性功与气道阻力显著相关，但与年龄无关。
肺容积对于解释肺顺应性和呼吸功很重要，因此在评估呼吸力学时必须予以考虑。相比之下，呼吸功主要受气道阻力影响。随着年龄的增长，肺顺应性和呼吸功仅有小幅下降。
