[对在西西伯利亚南部和克里米亚引发动物流行病的禽流感病毒分离株的分子生物学分析]

[Molecular-biologic analysis of avian influenza virus isolates which caused epizootics on the south of West Siberia and in Crimea].

作者信息

Onishchenko G G, Berezhnov S P, Shestopalov A M, Alekseev A Iu, Ternovoĭ V A, Khaĭtovich A B, Kroviakova M T, Netesov S V, Drozdov I G

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2007 Sep-Oct(5):28-32.

PMID:18041121

Abstract

The objective of the study was to determine reasons of poultry deaths in Crimea Republic in December 2005 as well as isolation, identification, and comparative analysis of pathogens, which caused epizootics in Siberia and Crimea. During epizootic in poultry in North-East Crimea highly pathogenic avian influenza virus H5N1 was isolated. Phylogenetic analysis of RNA sequences revealed that they belong to one big cluster. Isolated strain was close to viruses, which caused epizootic in July-August 2005 in the south of West Siberia. Conclusion about the high importance of the south of West Siberia in spreading of highly pathogenic influenza viruses H5N1 in Eurasia was made.

摘要

该研究的目的是确定2005年12月克里米亚共和国家禽死亡的原因，以及对在西伯利亚和克里米亚引发动物流行病的病原体进行分离、鉴定和比较分析。在克里米亚东北部家禽发生动物流行病期间，分离出了高致病性H5N1禽流感病毒。对RNA序列的系统发育分析表明，它们属于一个大的簇。分离出的毒株与2005年7月至8月在西西伯利亚南部引发动物流行病的病毒相近。得出了西西伯利亚南部在高致病性H5N1流感病毒在欧亚大陆传播中具有高度重要性的结论。