对β-淀粉样蛋白聚集有活性的新型多酚类物质。

New polyphenols active on beta-amyloid aggregation.

作者信息

Rivière Céline, Richard Tristan, Vitrac Xavier, Mérillon Jean-Michel, Valls Josep, Monti Jean-Pierre

机构信息

Laboratoire de physique et biophysique, Institut des Sciences de Vigne et du Vin, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.

出版信息

Bioorg Med Chem Lett. 2008 Jan 15;18(2):828-31. doi: 10.1016/j.bmcl.2007.11.028. Epub 2007 Nov 17.

DOI:10.1016/j.bmcl.2007.11.028

PMID:18042380

Abstract

New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.

摘要

新型多酚类已针对β-淀粉样肽聚集进行了测试。我们鉴定出四种新型多酚，它们可能是阿尔茨海默病中有效的纤维状蛋白抑制剂：锦葵色素及其糖苷以及仙茅苷B和D。我们认为具有特定C(6)-连接体-C(6)结构的分子可能是有效的抑制剂。从针对黄烷-3-醇家族报道的结果来看，它们对完整肽（1-40和1-42）的抗淀粉样蛋白生成作用可能涉及多个结合位点。