送上夹子：真核生物中DNA跨损伤合成的调控
Send in the clamps: control of DNA translesion synthesis in eukaryotes.
作者信息
Jansen Jacob G, Fousteri Maria I, de Wind Niels
机构信息
Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
出版信息
Mol Cell. 2007 Nov 30;28(4):522-9. doi: 10.1016/j.molcel.2007.11.005.
The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage.
通过跨损伤合成（TLS）对受损DNA模板进行复制与诱变和致癌作用相关。本观点讨论了TLS可能受到控制的不同层面，并提出了一个针对严重扭曲螺旋的DNA损伤的TLS模型，该模型认为Rad9-Hus1-Rad1 DNA损伤信号钳起决定性作用。这种钳在DNA损伤信号传导和TLS中的双重作用可能对确定细胞对DNA损伤的反应具有深远影响。
Zotero 插件