Fiaccadori E, Borghetti A
Istituto di Clinica Medica e Nefrologia, Università degli Studi di Parma.
Ann Ital Med Int. 1991 Oct-Dec;6(4):402-7.
Derangements of respiratory muscle function play a key role in the pathogenesis of respiratory failure, as they are able to determine respiratory pump failure and ventilatory insufficiency. Undernutrition negatively influences respiratory muscle function both directly through loss of contractile elements, and indirectly, through worsening or induction of muscle composition derangements. The present review focuses on the importance of undernutrition as a pathogenetic factor of altered respiratory muscle function: respiratory muscle structure and function derangements in both animal models of undernutrition and in undernourished subjects without lung disease are described. The pathophysiology of respiratory muscles in undernourished patients with lung disease is also discussed, along with the complex relationships between undernutrition and some other "metabolic" factors of ventilatory insufficiency.
呼吸肌功能紊乱在呼吸衰竭的发病机制中起关键作用，因为它们能够导致呼吸泵衰竭和通气不足。营养不良通过收缩元件的丧失直接对呼吸肌功能产生负面影响，并且通过肌肉组成紊乱的恶化或诱发间接产生负面影响。本综述着重探讨营养不良作为呼吸肌功能改变的致病因素的重要性：描述了营养不良动物模型和无肺部疾病的营养不良受试者的呼吸肌结构和功能紊乱。还讨论了患有肺部疾病的营养不良患者呼吸肌的病理生理学，以及营养不良与通气不足的其他一些“代谢”因素之间的复杂关系。
