Foerster Claudia G, Langenbucher Achim, Cursiefen Claus, Kruse Friedrich E, Seitz Berthold
Department of Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany.
Cornea. 2007 Dec;26(10):1182-3. doi: 10.1097/ICO.0b013e318151f8cc.
To compare the time necessary for complete epithelial healing after penetrating keratoplasty carried out for various corneal dystrophies.
In a retrospective single-center study, 679 eyes that underwent nonmechanical keratoplasty were evaluated concerning postoperative epithelial healing time. On the basis of corneal pathology, the eyes were divided into 5 groups: group 1, lattice dystrophy (n = 9); group 2, macular dystrophy (n = 16); group 3, Fuchs dystrophy (n = 207); group 4, granular dystrophy (n = 13); group 5, keratoconus (n = 434). After keratoplasty, the time necessary for complete healing of the epithelial defect was compared among the groups.
In lattice dystrophy, 22% showed delayed healing, in contrast to 0% in granular dystrophy. Mean time necessary for healing in group 1 (8.8 +/- 9.4 days) was significantly longer than in group 2 (2.5 +/- 2.5 days, P = 0.003), group 3 (4.4 +/- 4.1 days, P = 0.09), group 4 (2.2 +/- 1.4 days, P = 0.003), and group 5 (3.1 +/- 2.7 days, P = 0.005).
In patients with lattice dystrophy, delayed epithelial healing after penetrating keratoplasty may be anticipated. Patients should be counseled accordingly.
比较针对各种角膜营养不良进行穿透性角膜移植术后上皮完全愈合所需的时间。
在一项回顾性单中心研究中，对679只接受非机械性角膜移植的眼睛的术后上皮愈合时间进行了评估。根据角膜病理情况，将这些眼睛分为5组：第1组，格子状营养不良（n = 9）；第2组，斑状营养不良（n = 16）；第3组，富克斯营养不良（n = 207）；第4组，颗粒状营养不良（n = 13）；第5组，圆锥角膜（n = 434）。角膜移植术后，比较各组上皮缺损完全愈合所需的时间。
在格子状营养不良中，22%表现出愈合延迟，而颗粒状营养不良中这一比例为0%。第1组愈合所需的平均时间（8.8±9.4天）明显长于第2组（2.5±2.5天，P = 0.003）、第3组（4.4±4.1天，P = 0.09）、第4组（2.2±1.4天，P = 0.003）和第5组（3.1±2.7天，P = 0.005）。
对于格子状营养不良患者，穿透性角膜移植术后可能会出现上皮愈合延迟。应相应地对患者进行咨询。
