Mohammadpour Mehrdad, Jabbarvand Mahmood, Javadi Mohammad Ali
Eye Research Center and Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Cornea. 2007 Dec;26(10):1285-7. doi: 10.1097/ICO.0b013e318150d371.
To report a case with focal corneal decompensation after filtering surgery with inadvertent inadequate irrigation of mitomycin C (MMC).
Case report and review of literature.
A 25-year-old man first referred with the complaint of photophobia. His ocular examinations revealed diffuse keratic precipitates and many iris nodules in both eyes. The primary diagnosis was idiopathic bilateral granulomatous anterior uveitis. The intraocular pressure (IOP) gradually increased in the left eye and was not controlled with a prescription of topical antiglaucoma medications. As the disease progressed, the left eye underwent filtering surgery with MMC 0.02%. The postoperative period was uneventful, and the anterior chamber was deep after surgery. The IOP was controlled without medications; however; the inferior third of the cornea was edematous because of severe endothelial dysfunction.
Inadequate irrigation of MMC during filtering surgery can cause focal corneal decompensation.
报告1例滤过性手术后因丝裂霉素C（MMC）冲洗不充分导致局限性角膜失代偿的病例。
病例报告及文献复习。
一名25岁男性因畏光前来就诊。眼部检查发现双眼均有弥漫性角膜后沉着物及多个虹膜结节。初步诊断为特发性双侧肉芽肿性前葡萄膜炎。左眼眼压逐渐升高，局部抗青光眼药物治疗无法控制。随着病情进展，左眼接受了0.02%MMC滤过性手术。术后恢复顺利，术后前房较深。眼压无需药物即可控制；然而，由于严重的内皮功能障碍，角膜下三分之一出现水肿。
滤过性手术中MMC冲洗不充分可导致局限性角膜失代偿。
