白血病脓毒症患儿的混合细菌-病毒感染
Mixed bacterial-viral infections in septic children with leukemia.
作者信息
Koskenvuo Minna, Möttönen Merja, Rahiala Jaana, Saarinen-Pihkala Ulla M, Riikonen Pekka, Waris Matti, Ziegler Thedi, Uhari Matti, Ruuskanen Olli, Salmi Toivo T
机构信息
Department of Pediatrics, Turku University Hospital, Turku, Finland.
出版信息
Pediatr Infect Dis J. 2007 Dec;26(12):1133-6. doi: 10.1097/INF.0b013e318146207c.
BACKGROUND
Febrile infections in children with leukemia are common. The occurrence of possible mixed bacterial-viral infections is unknown.
METHODS
We searched for viruses in leukemic children with blood culture-positive bacterial infections. The prospective multicenter survey included 156 febrile episodes in 51 children with acute leukemia. The mean follow-up time was 1.5 years per patient (27,743 patient-days at risk). Sixteen viruses were searched for from nasal swab and stool samples using virus culture, virus antigen detection, and polymerase chain reaction tests.
RESULTS
Bacterial blood cultures were positive in 19 (11%) febrile episodes among 17 children. In half of the septic episodes (11 of 19), a virus was also found. Rhinovirus and respiratory syncytial virus were the most common viruses detected.
CONCLUSIONS
Our findings suggest that invasive bacterial infections are commonly associated with viral infections in children with leukemia.
背景
白血病患儿发热感染很常见。可能的细菌 - 病毒混合感染的发生率尚不清楚。
方法
我们在血培养阳性的细菌感染白血病患儿中寻找病毒。这项前瞻性多中心调查纳入了51例急性白血病患儿的156次发热发作。每位患者的平均随访时间为1.5年（27,743个患者危险日）。使用病毒培养、病毒抗原检测和聚合酶链反应试验从鼻拭子和粪便样本中检测16种病毒。
结果
17名儿童的19次（11%）发热发作中血培养细菌呈阳性。在一半的败血症发作中（19次中的11次）也发现了病毒。鼻病毒和呼吸道合胞病毒是检测到的最常见病毒。
结论
我们的研究结果表明，白血病患儿的侵袭性细菌感染通常与病毒感染有关。
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