[Lipid peroxidation and myocardial contractile function in the post-ischemic period depending on the level of hypothermic protection of the heart].

The experiments on rats isolated hearts showed lipid peroxidation state to depend on myocardial cooling level in ischemic period. Cooling to 8-12 degrees C does not induce significant impairment in the system of lipid peroxidation/antioxidant activity, thus preventing the development of reperfusion impairment in cardiac activity restoration. Temperature decrease to 4-6 degrees C during the ischemic period results in lipid peroxidation, antioxidant cell system exhaustion and impairment of contractive myocardial function in reperfusion.