Averev Ia F, Talalaev S V, Oberemok A V
Biull Eksp Biol Med. 1991 Oct;112(10):389-91.
Ethacrynic acid (10 mg/kg subcutaneously 15 days) significantly facilitated the experimental glomerulonephritis in rats. The efficacy of diuretic was confirmed by the improvement of the functional characteristics (the degree of proteinuria, the plasma contents of protein and urea, the creatinine excretion), and by the results of the histological investigation, especially at the second phase of the pathological process.
依他尼酸(皮下注射,10毫克/千克,共15天)显著加重了大鼠实验性肾小球肾炎。通过功能特性(蛋白尿程度、血浆蛋白和尿素含量、肌酐排泄)的改善以及组织学研究结果,尤其是在病理过程的第二阶段,证实了利尿效果。