Perreau-Linck Elisabeth, Beauregard Mario, Gravel Paul, Paquette Vincent, Soucy Jean-Paul, Diksic Mirko, Benkelfat Chawki
Perreau-Linck, Beauregard, Paquette-Department of Psychology, University of Montréal, Que.
J Psychiatry Neurosci. 2007 Nov;32(6):430-4.
Little is known about the specific contribution of serotonin (5-HT) to the neurobiology of emotion and mood in healthy people. In an exploratory study, we sought to investigate the effect of rapid and sustained changes of emotional state on the trapping of 11C-labelled alpha-methyl-L-tryptophan (11C-alphaMtrp) used as a proxy of 5-HT synthesis, using positron emission tomography (PET).
In a within-subject repeated-measure design, participants recalled autobiographical memories to self-induce sadness, happiness and a neutral emotional state during scanning to measure brain trapping of 11C-alphaMtrp. Three separate scan acquisitions, counterbalanced for order across subjects, took place at the McConnell Brain Imaging Center, Montréal.
Whole brain analysis revealed positive and negative correlations between experienced levels of emotions and 11C-alphaMtrp trapping in the right anterior cingulate cortex.
These findings point to a mechanism whereby state-related changes in a proxy of 5-HT synthesis underscore aspects of the self-regulation of normal mood.
关于血清素(5-羟色胺,5-HT)对健康人情绪和心境神经生物学的具体作用,目前所知甚少。在一项探索性研究中,我们试图利用正电子发射断层扫描(PET),研究情绪状态的快速和持续变化对用作5-HT合成指标的11C标记的α-甲基-L-色氨酸(11C-αMtrp)摄取的影响。
在一项受试者内重复测量设计中,参与者在扫描期间回忆自传式记忆,以自我诱发悲伤、快乐和中性情绪状态,从而测量大脑对¹¹C-αMtrp的摄取。在蒙特利尔的麦康奈尔脑成像中心进行了三次单独的扫描采集,扫描顺序在受试者之间进行了平衡。
全脑分析显示,右前扣带回皮层中情绪体验水平与11C-αMtrp摄取之间存在正相关和负相关。
这些发现指出了一种机制,即5-HT合成指标中与状态相关的变化突出了正常情绪自我调节的某些方面。