通过气相色谱/负离子化学电离质谱法对硫代氨基甲酸盐进行分析。
The analysis of thiocarbamides by gas chromatography/negative-ion chemical-ionization mass spectrometry.
作者信息
Watson D G, Bates C D, Skellern G G, Mairs R, Martin S
机构信息
Department of Pharmacy, University of Strathclyde, Glasgow, UK.
出版信息
Rapid Commun Mass Spectrom. 1991 Mar;5(3):141-2. doi: 10.1002/rcm.1290050311.
Thiocarbamides were converted to their di-N-pentafluorobenzyl (PFB) derivatives and analysed by gas chromatography/negative-ion chemical-ionization mass spectrometry with methane as reagent gas. The PFB derivatives of the 2-thiouracils gave mass spectra in which the ion current was carried largely by an ion arising from [M-PFB]-. The derivative was used in the determination of the uptake and metabolism of thiocarbamides by cultures of melanoma cells.
硫脲被转化为其二 - N - 五氟苄基（PFB）衍生物，并通过以甲烷作为反应气的气相色谱/负离子化学电离质谱法进行分析。2 - 硫脲嘧啶的PFB衍生物给出的质谱中，离子电流主要由[M - PFB]-产生的离子携带。该衍生物用于测定黑色素瘤细胞培养物对硫脲的摄取和代谢。
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