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核苷对艾氏腹水癌细胞中核酸和蛋白质合成的影响。

Effect of nucleosides on the synthesis of nucleic acids and proteins in Ehrlich ascites carcinoma cells.

作者信息

Foltínová I, Kuzela S

出版信息

Neoplasma. 1976;23(2):223-6.

PMID:180442
Abstract

The synthesis of nucleic acids and proteins in whole cells of Ehrlich ascites carcinoma was inhibited by adenosine and by several natural-adenosine-related compounds. The inhibitory effect of adenosine was more pronounced than that of other nucleosides tested (guanosine, inosine, cytidine, uridine and thymidine). The synthetic processes examined were only moderately inhibited by adenine nucleotides (ATP, ADP, AMP, NAD, cyclic 3',5'-AMP and its dibutyryl derivative). Respiration and aerobic glycolysis were not affected significantly by the nucleoside tested.

摘要

艾氏腹水癌细胞全细胞中核酸和蛋白质的合成受到腺苷及几种天然腺苷相关化合物的抑制。腺苷的抑制作用比所测试的其他核苷(鸟苷、肌苷、胞苷、尿苷和胸苷)更为显著。所检测的合成过程仅受到腺嘌呤核苷酸(ATP、ADP、AMP、NAD、环3',5'-AMP及其二丁酰衍生物)的中度抑制。所测试的核苷对呼吸作用和好氧糖酵解没有显著影响。

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