Huang H H, Marshall S, Meites J
Neuroendocrinology. 1976;20(1):21-34. doi: 10.1159/000122463.
Cycling was induced in old non-cyclic, constant estrous rats by daily injections of progesterone, ACTH or L-dopa or by subjection to ether stress. Progesterone and ACTH were the most effective agents used for re-establishing estrous cycles in these rats. Most of the progesterone- and ACTH-treated rats showed regular cycles, and their ovaries had many corpora lutea; they also showed proestrous serum LH surges. Ether stress and L-dopa mostly induced irregular cycles and fewer corpora lutea in the ovaries; a smaller number of these rats showed proestrous LH surges. After treatment with each of these agents was discontinued, most of the rats returned to constant estrus or irregular cycling.
通过每日注射孕酮、促肾上腺皮质激素（ACTH）或左旋多巴，或使其遭受乙醚应激，诱导老年非周期性、持续发情大鼠出现发情周期。孕酮和促肾上腺皮质激素是用于在这些大鼠中重新建立发情周期的最有效药物。大多数经孕酮和促肾上腺皮质激素处理的大鼠表现出规律的周期，其卵巢中有许多黄体；它们还表现出发情前期血清促黄体生成素（LH）激增。乙醚应激和左旋多巴大多诱导出不规律的周期，卵巢中的黄体较少；这些大鼠中较少数量表现出发情前期LH激增。在停止用这些药物中的每一种进行治疗后，大多数大鼠恢复到持续发情或不规律的发情周期。
