暴露于六氯苯对灵长类动物卵巢表面上皮的影响：一项定量研究。

Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: a quantitative study.

作者信息

Sims D E, Singh A, Donald A, Jarrell J, Villeneuve D C

机构信息

Department of Anatomy and Physiology, Faculty of Veterinary Medicine, University of Prince Edward Island, Charlottetown, Canada.

出版信息

Histol Histopathol. 1991 Oct;6(4):525-9.

PMID:1804430

Abstract

Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in this study. At the lowest dose used, 0.1 mg/kg body weight, a dosage that is associated with follicular degeneration, HCB caused quantifiable changes in length-to-width ratios of OSE. Measurement of cell shape by light microscopy offers a reliable indication of OSE changes induced by HCB.

摘要

六氯苯（HCB）是一种杀菌剂，也是世界工业化地区日益受到关注的污染物。生殖功能衰竭是HCB对哺乳动物的影响之一。本研究观察了食蟹猴口服HCB后卵巢表面上皮（OSE）细胞形态的改变。在使用的最低剂量（0.1毫克/千克体重，这一剂量与卵泡变性有关）下，HCB导致OSE长宽比发生可量化的变化。通过光学显微镜测量细胞形态可为HCB诱导的OSE变化提供可靠指标。