Lenssen Josephine, Stolk Jan
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Int J Chron Obstruct Pulmon Dis. 2007;2(2):131-9.
A common feature of lung disorders with poor treatment options, including emphysema, is a failure to initiate a repair process of the alveolar epithelium. Several putative stem cell niches in the lung thought to be involved in lung homeostasis have been described. Apparently, under pathophysiological conditions these resident progenitor cells are unable to recover damaged alveolar epithelium, in particular in emphysema. The potential therapeutic effect of retinoic acid receptor agonists on various resident lung progenitor cells is reviewed.
包括肺气肿在内的治疗选择有限的肺部疾病的一个共同特征是肺泡上皮修复过程启动失败。已经描述了肺中几个被认为与肺稳态有关的假定干细胞龛。显然，在病理生理条件下，这些驻留祖细胞无法修复受损的肺泡上皮，尤其是在肺气肿中。本文综述了维甲酸受体激动剂对各种肺驻留祖细胞的潜在治疗作用。
