Kumar Anand, Ajilore Olusola, Kepe Vladimir, Barrio Jorge R, Small Gary
Department of Psychiatry, the Semel Institute for Neuroscience, University of California, Los Angeles, CA 90024, USA.
Int J Geriatr Psychiatry. 2008 Jun;23(6):555-63. doi: 10.1002/gps.1941.
Disorders of mood and cognition overlap in the elderly and there is an emerging consensus that both groups of disorders share neurobiological substrates.
Salient peer reviewed articles focusing on late-life depression, structural neuroimaging and recent developments in positron emission tomography based in vivo protein imaging.
Epidemiological and clinical evidence indicates that mood and cognition in the elderly are clinically inter-related and common neurobiological mechanisms may underlie both groups of disorders. Degenerative, vascular and related mechanisms like genetically programmed abnormal protein deposition may provide the underlying neurobiological links between these disorders.
Modern neuroimaging approaches such as positron emission tomography (PET) based in vivo protein binding may help further elucidate common pathophysiological mechanisms and assist in the early identification of patients at risk for developing dementia over time. These developments have important mechanistic and public health significance in the elderly.
情绪和认知障碍在老年人中相互重叠，并且越来越多的人达成共识，即这两组障碍共享神经生物学基础。
重点关注晚年抑郁症、结构神经影像学以及基于正电子发射断层扫描的体内蛋白质成像最新进展的重要同行评审文章。
流行病学和临床证据表明，老年人的情绪和认知在临床上相互关联，两组障碍可能存在共同的神经生物学机制。退行性、血管性及相关机制，如基因编程异常蛋白质沉积，可能为这些障碍之间提供潜在的神经生物学联系。
基于正电子发射断层扫描（PET）的体内蛋白质结合等现代神经影像学方法，可能有助于进一步阐明常见的病理生理机制，并协助早期识别随着时间推移有患痴呆症风险的患者。这些进展在老年人中具有重要的机制和公共卫生意义。
