Jacobs Stefan, Schulz Stefan
Institut für Pharmakologie und Toxikologie, Universität Würzburg, Würzburg, Germany.
Mol Cell Endocrinol. 2008 May 14;286(1-2):58-62. doi: 10.1016/j.mce.2007.10.005. Epub 2007 Oct 16.
The somatostatin receptor subtypes 1-5 (sst(1)-sst(5)) exhibit different intracellular trafficking and endosomal sorting after agonist exposure. The internalization of the somatostatin receptor subtypes sst(2), sst(3) and sst(5) occurs to a much higher extent after somatostatin exposure than of sst(1) or sst(4). After endocytosis, sst(2) and sst(5) recycle to the plasma membrane, whereas sst(3) is predominantly down-regulated. This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins.
生长抑素受体亚型1 - 5（sst(1)-sst(5)）在激动剂作用后表现出不同的细胞内运输和内体分选。生长抑素暴露后，生长抑素受体亚型sst(2)、sst(3)和sst(5)的内化程度比sst(1)或sst(4)高得多。内吞作用后，sst(2)和sst(5)循环回到质膜，而sst(3)主要被下调。本综述将聚焦于sst(2)、sst(3)和sst(5)细胞内差异运输的分子机制，并讨论我们目前对生长抑素受体相互作用蛋白的了解。
