Bitigen Atila, Cevik Cihan, Demir Durmus, Tanalp Ali Cevat, Dundar Cihan, Tigen Kursat, Mutlu Bulent, Basaran Yelda
Cardiology Department, Kosuyolu Heart and Research Hospital, Istanbul, Turkey.
Congest Heart Fail. 2007 Nov-Dec;13(6):323-7. doi: 10.1111/j.1527-5299.2007.07430.x.
The authors investigated the relationship between angiotensin-converting enzyme (ACE) genotype and left ventricular functions in an obese population and compared their findings with controls. Ninety-six obese patients and 50 controls were enrolled. Obesity was subgrouped into mild (body mass index [BMI] 25-29.9 kg/m(2)), moderate (BMI 30-34.9 kg/m(2)), and significant (BMI > or =35 kg/m(2)). Body fat distribution was categorized according to waist-to-hip ratio and waist circumference. Left ventricular systolic and diastolic functions were evaluated by echocardiography. ACE gene polymorphism was investigated by standard polymerase chain reaction, and frequency distributions were calculated for the subgroups. Systolic functional indices were found to be increased in mild and moderate obesity subgroups. The obese population had increased left ventricular diameters. None of the patients had systolic dysfunction, while diastolic dysfunction was significantly more common in the obese group; the frequency of diastolic dysfunction was proportionally increased with body mass index. Diastolic dysfunction was more common in persons with abdominal obesity. ACE DD genotype frequency was increased in moderately and significantly obese subgroups and also in all obese patients with diastolic dysfunction.
作者研究了肥胖人群中血管紧张素转换酶（ACE）基因型与左心室功能之间的关系，并将他们的研究结果与对照组进行了比较。招募了96名肥胖患者和50名对照。肥胖被分为轻度（体重指数[BMI]25 - 29.9 kg/m²）、中度（BMI 30 - 34.9 kg/m²）和重度（BMI≥35 kg/m²）。根据腰臀比和腰围对体脂分布进行分类。通过超声心动图评估左心室的收缩和舒张功能。通过标准聚合酶链反应研究ACE基因多态性，并计算各亚组的频率分布。发现轻度和中度肥胖亚组的收缩功能指标增加。肥胖人群的左心室直径增大。所有患者均无收缩功能障碍，而舒张功能障碍在肥胖组中明显更常见；舒张功能障碍的频率与体重指数成比例增加。舒张功能障碍在腹型肥胖者中更常见。ACE DD基因型频率在中度和重度肥胖亚组以及所有有舒张功能障碍的肥胖患者中均增加。
