Locatelli A, Andreani M, Ghidini A, Verderio M, Pizzardi A, Vergani P, Salafia C M
Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.
J Perinatol. 2008 Feb;28(2):97-101. doi: 10.1038/sj.jp.7211876. Epub 2007 Nov 29.
To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).
From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at <or=24.6 weeks, we excluded those who did not develop severe oligohydramnios (n=12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.
Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC.
A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.
探讨经腹羊膜腔灌注（TA）对羊膜（A）和脐带（UC）组织学的影响。
在一组56例妊娠小于或等于24.6周胎膜早破（PROM）的单胎妊娠中，我们排除了未发生严重羊水过少的患者（n = 12）。在这44例患者中，29例同意接受TA，15例拒绝该操作。TA采用生理盐水进行。
同意接受TA的女性平均接受了3次操作，PROM时的孕周为18.7周，分娩时的孕周为26.1周，潜伏期为50天。与拒绝该操作的受试者相比，TA对临床变量有有益影响，主要表现为潜伏期延长。TA与对A或UC的组织学特征无明显影响。
即使长时间接触生理盐水，A和UC的组织学也未受到显著影响。
