Rovin B H, Hebert L A
Department of Internal Medicine, Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Kidney Int. 2007 Dec;72(12):1423-6. doi: 10.1038/sj.ki.5002656.
Diuretic monotherapy is the current recommendation of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure for initial antihypertensive therapy. There is mounting concern, however, that the benefits of diuretic's superior blood pressure control may be offset by its multiple metabolic disturbances that increase cardiovascular risk. Reungjui et al. document a new concern, nephrotoxicity by thiazide monotherapy. This and other recently published evidence of diuretic's 'dark side' is discussed.
利尿单药治疗是美国国家高血压预防、检测、评估与治疗联合委员会目前对于初始抗高血压治疗的推荐方案。然而，人们越来越担心，利尿剂卓越的血压控制效果所带来的益处可能会被其多种代谢紊乱所抵消，而这些代谢紊乱会增加心血管疾病风险。Reungjui等人记录了一个新的问题，即噻嗪类单药治疗的肾毒性。本文将讨论这一问题以及其他最近发表的有关利尿剂“阴暗面”的证据。
Zotero 插件