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脂肪摄入量和抗高血压药物治疗对血清脂质谱的影响:男性和女性高血压患者血清脂质的横断面调查。

The effect of fat intake and antihypertensive drug therapy on serum lipid profile: a cross-sectional survey of serum lipids in male and female hypertensives.

机构信息

Toxicology and Drug Research Center, National Institute of Nutrition (ICMR), Hyderabad, India.

出版信息

Mol Cell Biochem. 2010 Oct;343(1-2):37-47. doi: 10.1007/s11010-010-0496-4. Epub 2010 Jun 4.

Abstract

The present study aimed to investigate the effect of betablocker with diuretics therapy on serum cholesterol and high density lipoprotein (HDL-C) lipids in cross-sectional data (age, sex, weight, and body mass index (BMI), smoking/alcoholic consumption) and supplemented vegetarian low-fat diet with daily low fat energy intake, salt intake, duration of drug therapy, and serum protein as effective measures of lowering blood pressure among hypertensives in both males and females. Hypertensive patients on betablocker and/or thiazide therapy were compared in cross-section study with their age, blood pressure, fat intake, serum lipid profile, BMI, and serum albumin in males and females. Dietary fat intake and serum lipid profile were income related. Betablocker and diuretics therapy in combination with dietary fat intervention was beneficial for prolonged dyslipidemia control. Serum cholesterol level was main contributing factor dependent on BMI, duration of drug, and socio-economic factors. Fat intake contributed in hypertension and serum cholesterol levels. A cross-sectional data analysis showed beneficial effects of "low fat-salt-smoking-alcohol consumption and combined polyunsaturated fatty acid with antihypertensive therapy approach" to keep normal dyslipidemia and hypertension. Low fat intake, low salt, smoking, alcohol consumption, and combination of dietary oil supplements with lipid betablockers and diuretic modulators were associated with low hypertension and controlled dyslipidemia in Asian sedentary population.

摘要

本研究旨在探讨β受体阻滞剂联合利尿剂治疗对横断面数据(年龄、性别、体重和体重指数(BMI)、吸烟/饮酒)中血清胆固醇和高密度脂蛋白(HDL-C)脂质的影响,并补充素食低脂饮食,每日低脂能量摄入、盐摄入量、药物治疗持续时间和血清蛋白作为降低男性和女性高血压患者血压的有效措施。在横断面研究中,比较了接受β受体阻滞剂和/或噻嗪类利尿剂治疗的高血压患者与其年龄、血压、脂肪摄入量、血清脂质谱、BMI 和血清白蛋白在男性和女性中的差异。膳食脂肪摄入量与血清脂质谱呈正相关。β受体阻滞剂和利尿剂联合治疗与饮食脂肪干预相结合,有利于延长血脂异常控制。血清胆固醇水平是主要的影响因素,取决于 BMI、药物使用时间和社会经济因素。脂肪摄入量与高血压和血清胆固醇水平有关。横断面数据分析显示,“低盐、低脂肪、戒烟、限酒以及联合使用降压治疗和多不饱和脂肪酸”的方法对保持正常血脂异常和高血压有有益的作用。在亚洲久坐不动的人群中,低脂摄入、低盐、吸烟、饮酒以及饮食中油类补充与血脂β受体阻滞剂和利尿剂调节剂联合使用与较低的高血压和控制良好的血脂异常有关。

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