Madden Leigh A, Sandström Marie E, Lovell Ric J, McNaughton Lars
Post Graduate Medical Institute and Institute of Clinical Biosciences, University of Hull, Cottingham Road, Hull HU67RX, UK.
Amino Acids. 2008 May;34(4):511-6. doi: 10.1007/s00726-007-0004-7. Epub 2007 Nov 29.
Heat shock proteins (Hsp) are well known to be expressed in response to a range of cellular stresses. They are known to convey protection against protein denaturation and a subsequent immediate stress. Inducible heat shock protein 70 (Hsp70) is among the most studied of these stress proteins and its role and function are discussed here in terms of thermal and in particular exercise preconditioning. Preconditioning has been shown to confer cellular protection via expression Hsp, which may be of benefit in preventing protein damage following subsequent periods of exercise. Many studies have used animal models to gather data on Hsp70 and these and the most recent human studies are discussed.
热休克蛋白（Hsp）因能响应一系列细胞应激而表达广为人知。它们能防止蛋白质变性及随后的即时应激。诱导型热休克蛋白70（Hsp70）是这些应激蛋白中研究最多的，本文将从热应激，特别是运动预处理方面讨论其作用和功能。预处理已被证明可通过热休克蛋白的表达赋予细胞保护作用，这可能有助于预防后续运动期间的蛋白质损伤。许多研究使用动物模型收集有关Hsp70的数据，本文将讨论这些研究以及最新的人体研究。
