Shobha J C, Raghuram T C, Kumar A D, Krishnaswamy K
Department of Pharmacology Gandhi Medical College, Hyderabad, India.
Eur J Clin Pharmacol. 1991;41(4):359-61. doi: 10.1007/BF00314968.
In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.
在发展中国家，糖尿病患者常常伴有不同程度的营养不良。以安替比林作为原型药物，评估了营养不良与非胰岛素依赖型糖尿病（NIDDM）对药物代谢酶系统的联合作用。所有患者均在接受治疗，且其血浆葡萄糖值在正常范围内。安替比林的曲线下面积在所有组中相似。虽然正常糖尿病患者的动力学参数均未改变，但与营养不良的对照组相比，营养不良的糖尿病患者安替比林的清除率降低，半衰期延长，分布容积增加。结果表明，当血糖得到良好控制时，糖尿病本身可能不会影响安替比林的动力学，但在存在营养不良的情况下，它会显著改变药物的处置。
