通过安替比林血浆半衰期测定营养不良中的微粒体酶。
Microsomal enzymes in malnutrition as determined by plasma half life of antipyrine.
作者信息
Krishnaswamy K, Naidu A N
出版信息
Br Med J. 1977 Feb 26;1(6060):538-40. doi: 10.1136/bmj.1.6060.538.
Abstract
Nutritional-pharmacological interactions were studied in a group of malnourished subjects. Antipyrine was used to evaluate mixed-function oxidase in man. The results indicated that the rate of disappearance of antipyrine from plasma was strongly influenced by the nutritional status of the individual. The half life of antipyrine was modified in undernourished subjects and those with nutritional oedema. This finding indicates that drug regimens may have to be adjusted in patients who have antipyrine half lives that are shorter or longer than normal. Otherwise drug treatment may be inadequate or, in patients with impaired microsomal enzyme activity, potentially dangerous.
摘要
在一组营养不良的受试者中研究了营养 - 药理相互作用。使用安替比林来评估人体中的混合功能氧化酶。结果表明，安替比林从血浆中消失的速率受个体营养状况的强烈影响。在营养不良的受试者和有营养性水肿的受试者中，安替比林的半衰期发生了改变。这一发现表明，对于安替比林半衰期比正常情况短或长的患者，可能必须调整药物治疗方案。否则，药物治疗可能不足，或者对于微粒体酶活性受损的患者，可能存在危险。
相似文献
1
Microsomal enzymes in malnutrition as determined by plasma half life of antipyrine.通过安替比林血浆半衰期测定营养不良中的微粒体酶。
Br Med J. 1977 Feb 26;1(6060):538-40. doi: 10.1136/bmj.1.6060.538.
2
Antipyrine kinetics in undernourished diabetics.营养不良型糖尿病患者的安替比林动力学
Eur J Clin Pharmacol. 1991;41(4):359-61. doi: 10.1007/BF00314968.
3
4
Plasma antipyrine half-life and hepatic microsomal antipyrine hydroxylase activity in rabbits.
Pharmacology. 1973;10(6):329-37. doi: 10.1159/000136454.
5
Induction of hepatic microsomal enzymes after brief administration of rifampicin in man.
Gastroenterology. 1977 May;72(5 Pt 1):924-6.
6
Determinants of serum antipyrine half-lives in patients with liver disease.肝病患者血清安替比林半衰期的决定因素。
Gut. 1973 Jul;14(7):569-73. doi: 10.1136/gut.14.7.569.
7
Anomalous results of studies on drug interaction in man. I. Nortriptyline and antipyrine.人体药物相互作用研究的异常结果。I. 去甲替林与安替比林。
Pharmacology. 1975;13(2):101-11. doi: 10.1159/000136891.
8
Hepatic antipyrine metabolism in malnourished patients: influence of the type of malnutrition and course after nutritional rehabilitation.
Am J Clin Nutr. 1985 Jun;41(6):1257-64. doi: 10.1093/ajcn/41.6.1257.
9
The plasma half-life of antipyrine in chromic uraemic and normal subjects.安替比林在慢性尿毒症患者和正常受试者体内的血浆半衰期。
Br J Clin Pharmacol. 1975 Aug;2(4):339-43. doi: 10.1111/j.1365-2125.1975.tb02781.x.
10
Relationship between plasma antipyrine half-lives and hepatic microsomal drug metabolism in dogs.
Pharmacology. 1973;10(6):317-28. doi: 10.1159/000136453.
引用本文的文献
1
Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women.哌喹暴露受妊娠、艾滋病毒和乌干达妇女营养状况的影响。
Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01013-20.
2
Lack of a significant change in caffeine metabolism in underweight children as determined by the caffeine breath test.通过咖啡因呼气试验测定，体重不足儿童的咖啡因代谢无显著变化。
Arch Dis Child. 2015 Jul;100(7):689-93. doi: 10.1136/archdischild-2014-308017. Epub 2015 Apr 20.
3
Antipyrine metabolite formation in children in the acute phase of malnutrition and after recovery.营养不良急性期及恢复后儿童中安替比林代谢物的形成
Br J Clin Pharmacol. 1980 Oct;10(4):363-8. doi: 10.1111/j.1365-2125.1980.tb01772.x.
4
Kinetics of sulphafurazole in undernutrition.营养不良状态下磺胺异恶唑的动力学
Br J Clin Pharmacol. 1980 Nov;10(5):499-502. doi: 10.1111/j.1365-2125.1980.tb01795.x.
5
Acetanilide pharmacokinetics in kwashiorkor.夸休可尔症中乙酰苯胺的药代动力学。
Br J Clin Pharmacol. 1980 May;9(5):525-6. doi: 10.1111/j.1365-2125.1980.tb05854.x.
6
The effect of malnutrition on the pharmacokinetics of phenylbutazone.营养不良对保泰松药代动力学的影响。
Clin Pharmacokinet. 1981 Mar-Apr;6(2):152-9. doi: 10.2165/00003088-198106020-00005.
7
Pharmacokinetics and plasma steady state levels of doxycycline in undernutrition.营养不足情况下强力霉素的药代动力学及血浆稳态水平
Br J Clin Pharmacol. 1982 Dec;14(6):785-9. doi: 10.1111/j.1365-2125.1982.tb02037.x.
8
Dietary influences on the kinetics of antipyrine and aminopyrine in human subjects.饮食对人体中安替比林和氨基比林动力学的影响。
Br J Clin Pharmacol. 1984 Feb;17(2):139-46. doi: 10.1111/j.1365-2125.1984.tb02328.x.
9
Influences of diet and nutrition on clinical pharmacokinetics.饮食和营养对临床药代动力学的影响。
Clin Pharmacokinet. 1988 Jun;14(6):325-46. doi: 10.2165/00003088-198814060-00002.
10
Drug metabolism and pharmacokinetics in malnourished children.营养不良儿童的药物代谢与药代动力学
Clin Pharmacokinet. 1989;17 Suppl 1:68-88. doi: 10.2165/00003088-198900171-00006.
本文引用的文献
1
Effect of environmental factors on drug metabolism: decreased plasma half-life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides.环境因素对药物代谢的影响：接触氯代烃类杀虫剂的工人中安替比林的血浆半衰期缩短。
Clin Pharmacol Ther. 1969 Sep-Oct;10(5):638-42. doi: 10.1002/cpt1969105638.
2
Serum -glutamyl transpeptidase activity in alcoholism.酗酒者血清γ-谷氨酰转肽酶活性
Clin Chim Acta. 1972 Jun;39(1):41-7. doi: 10.1016/0009-8981(72)90297-5.
3
Inter-relationships of nutrition and the metabolism of drugs.营养与药物代谢之间的相互关系。
Chem Biol Interact. 1974 Mar;8(3):193-206. doi: 10.1016/0009-2797(74)90041-6.
4
Clinical problems related to the use of drugs in malnutrition.与营养不良患者用药相关的临床问题。
Proc Nutr Soc. 1974 Dec;33(3):203-7. doi: 10.1079/pns19740040.
5
Polygenic factors controlling drug response.控制药物反应的多基因因素。
Med Clin North Am. 1974 Sep;58(5):951-63. doi: 10.1016/s0025-7125(16)32092-2.
6
Undernutrition and tetracycline half life.
Clin Chim Acta. 1976 Jan 16;66(2):157-64. doi: 10.1016/0009-8981(76)90052-8.
7
Effect of protein/energy nutrition on rat plasma corticosteroids and liver microsomal hydroxylase activity.蛋白质/能量营养对大鼠血浆皮质类固醇及肝脏微粒体羟化酶活性的影响。
Nutr Metab. 1975;18(1):49-54. doi: 10.1159/000175573.
8
Unaltered metabolism of antipyrine and tolbutamide in fasting man.空腹状态下人体中安替比林和甲苯磺丁脲代谢未受影响。
Clin Pharmacol Ther. 1975 Jun;17(6):650-6. doi: 10.1002/cpt1975176650.
9
Famine oedema.饥荒性水肿
Prog Food Nutr Sci. 1975;1(3):207-24.
10
Drug disposition and liver disease.药物处置与肝脏疾病
Drug Metab Rev. 1975;4(2):139-75. doi: 10.3109/03602537508993754.
Zotero 插件