基因易癫痫发作或抗癫痫发作表型及其相关行为共病。
Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities.
作者信息
McIntyre Dan C, Gilby Krista L
机构信息
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
出版信息
Epilepsia. 2007;48 Suppl 9:30-2. doi: 10.1111/j.1528-1167.2007.01398.x.
It was questioned whether amygdala kindling, a model of temporal lobe epilepsy, is under genetic control, and is associated with comorbid behavioral features. Initially, rats were selectively bred for speed of amygdala kindling, and, in subsequent generations, were assessed in behavioral paradigms to measure activity, emotionality, impulsivity, and learning. Clearly kindling was under genetic control, as two strains were developed to be either Fast or Slow to kindle, and each was associated with different neurological, electrophysiological and behavioral features. Behaviorally, the Fast rats appear much like humans with attention deficit hyperactivity disorder (ADHD), showing easy distraction, hyperactivity and impulsivity, compared to Slow rats.
杏仁核点燃作为颞叶癫痫的一种模型，是否受基因控制以及是否与共病行为特征相关，这是一个存在疑问的问题。最初，根据杏仁核点燃的速度对大鼠进行选择性育种，在随后的几代中，对它们在行为范式中进行评估，以测量活动、情绪、冲动性和学习能力。显然，点燃是受基因控制的，因为培育出了两种品系，一种点燃速度快，另一种点燃速度慢，并且每种品系都与不同的神经学、电生理学和行为特征相关。在行为方面，与慢燃大鼠相比，快燃大鼠表现得很像患有注意力缺陷多动障碍（ADHD）的人类，表现出容易分心、多动和冲动。
Zotero 插件