Hannesson D K, Pollock M S, Howland J G, Mohapel P, Wallace A E, Corcoran M E
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Epilepsy Behav. 2008 Jul;13(1):52-61. doi: 10.1016/j.yebeh.2008.02.007. Epub 2008 Mar 11.
Kindling in rats produces enduring behavioral changes that parallel the psychobehavioral disturbances frequently accompanying temporal lobe epilepsy. Some evidence suggests that the site of kindling is an important determinant of the type of behavioral changes observed following kindling, although this variable has not been systematically investigated. In the present experiments, the effects of amygdaloid kindling were assessed on a battery of behavioral tests we used previously to assess the effects of kindling in dorsal hippocampus or perirhinal cortex. Three generalized seizures were kindled with stimulation in or near the basolateral amygdala. One week later, rats were tested successively on measures of anxiety, activity, object recognition memory, and spatial working memory over a period of 3 weeks. Amygdaloid kindling produced increased anxiety, but spared all other behaviors assessed. This pattern of results is partially distinct from the previously described effects of perirhinal cortical kindling, which increases anxiety but also impairs object recognition memory, and is completely distinct from dorsal hippocampal kindling, which selectively increases activity and impairs spatial working memory. The observations suggest that kindling of distinct highly interconnected temporal lobe sites produces distinct patterns of behavioral comorbidity. The underlying mechanisms are thus most likely localized to intrinsic circuits at the site of seizure origination.
大鼠点燃效应会产生持久的行为变化，这些变化与颞叶癫痫常伴随的心理行为障碍相似。一些证据表明，点燃部位是点燃后所观察到的行为变化类型的重要决定因素，尽管这一变量尚未得到系统研究。在本实验中，我们使用先前评估背侧海马或梨状前皮质点燃效应时所用的一系列行为测试，来评估杏仁核点燃效应。通过在基底外侧杏仁核内或其附近进行刺激，引发三次全身性癫痫发作。一周后，在为期3周的时间里，依次对大鼠进行焦虑、活动、物体识别记忆和空间工作记忆等方面的测试。杏仁核点燃效应会增加焦虑，但并未影响所评估的其他所有行为。这一结果模式与先前描述的梨状前皮质点燃效应部分不同，梨状前皮质点燃效应会增加焦虑，但也会损害物体识别记忆；它与背侧海马点燃效应完全不同，背侧海马点燃效应会选择性地增加活动并损害空间工作记忆。这些观察结果表明，不同的高度相互连接的颞叶部位的点燃会产生不同的行为共病模式。因此，潜在机制很可能定位于癫痫发作起始部位的内在神经回路。
