斑马鱼中的插入诱变策略。
Insertional mutagenesis strategies in zebrafish.
作者信息
Sivasubbu Sridhar, Balciunas Darius, Amsterdam Adam, Ekker Stephen C
机构信息
Institute of Genomics and Integrative Biology, Council for Scientific and Industrial Research, Mall Road, Delhi 110007, India.
出版信息
Genome Biol. 2007;8 Suppl 1(Suppl 1):S9. doi: 10.1186/gb-2007-8-s1-s9.
Abstract
We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mechanisms and concepts of new transposon-based mutagenesis approaches under development, including prospects for conditional 'gene trapping' and 'gene breaking' approaches.
摘要
我们在此回顾斑马鱼插入诱变领域的一些最新进展。我们强调了丰富的逆转录病毒方法学的优点和局限性，并重点关注正在开发的基于新转座子的诱变方法的机制和概念，包括条件性“基因捕获”和“基因破坏”方法的前景。
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