蓝升麻中的生物碱和皂苷。

Alkaloids and saponins from blue cohosh.

作者信息

Ali Zulfiqar, Khan Ikhlas A

机构信息

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, MS 38677, USA.

出版信息

Phytochemistry. 2008 Feb;69(4):1037-42. doi: 10.1016/j.phytochem.2007.10.011. Epub 2007 Nov 28.

DOI:10.1016/j.phytochem.2007.10.011

PMID:18048069

Abstract

Blue cohosh, Caulophyllum thalictroides (L.) Michx. (Berberidaceae), is used primarily to cure menstrual disturbances and to ease childbirth. Alkaloids and saponins are considered to be responsible for its pharmacological activity. A detailed phytochemical investigation of blue cohosh resulted in the isolation of 15 compounds belonging to the alkaloids and the triterpene saponins. The structures of two alkaloids, caulophyllumines A (1) and B (2) and a saponin, cauloside H (3) both previously unknown were determined by spectroscopic techniques, including by 1- and 2-D NMR as well as by chemical analysis.

摘要

蓝升麻，即北美升麻（Caulophyllum thalictroides (L.) Michx.，小檗科），主要用于治疗月经紊乱和缓解分娩。生物碱和皂苷被认为是其药理活性的原因。对蓝升麻进行了详细的植物化学研究，分离出了15种属于生物碱和三萜皂苷的化合物。两种生物碱，升麻明A（1）和B（2）以及一种皂苷，升麻苷H（3），其结构此前均未知，通过光谱技术确定，包括一维和二维核磁共振以及化学分析。