Nikolova P, Kavaldzhieva B
Higher Institute of Medicine, Varna, Bulgaria.
J Hyg Epidemiol Microbiol Immunol. 1991;35(4):361-5.
Two groups of workers without clinical manifestations of intoxications were examined in the study. Workers in Group One were occupationally exposed to manganese (Mn) and in Group Two - to lead (Pb). Erythrocyte concentrations of adenyl nucleotides (AMP, ADP and ATP) as well as that of inorganic phosphorus (Pi) were determined. The authors also calculated both ratios ADP/Pi and ATP/ADP, the energy charge and phosphorylation potential. The metabolic processes in the erythrocytes of workers exposed to heavy metals but without clinical manifestations were found to intensify and become more pronounced in workers occupationally exposed to lead. Erythrocytes from workers occupationally exposed to lead featured higher ratios of ATP/ADP.
在该研究中，对两组无中毒临床表现的工人进行了检查。第一组工人职业性接触锰（Mn），第二组工人职业性接触铅（Pb）。测定了红细胞中腺苷酸（AMP、ADP和ATP）以及无机磷（Pi）的浓度。作者还计算了ADP/Pi和ATP/ADP的比率、能荷和磷酸化电位。结果发现，接触重金属但无临床表现的工人红细胞中的代谢过程增强，且在职业性接触铅的工人中更为明显。职业性接触铅的工人的红细胞具有更高的ATP/ADP比率。
