Donath Marc Y, Størling Joachim, Berchtold Lukas A, Billestrup Nils, Mandrup-Poulsen Thomas
The Clinic for Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland.
Endocr Rev. 2008 May;29(3):334-50. doi: 10.1210/er.2007-0033. Epub 2007 Nov 29.
The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.
细胞因子与β细胞的故事由来已久，始于1984年的体外发现，历经描述性和现象学研究，发展到信号通路、基因和蛋白质表达模式、分子及生化效应机制的详细图谱绘制，再到自发性糖尿病和转基因动物模型的体内研究。直到最近才开始采取措施将积累的令人信服的临床前数据转化为临床试验。本章旨在概述我们自己的团队以及其他实验室早期和近期的关键观察结果，这些结果有助于阐明从概念到临床转化的道路。
