Krysiak Robert, Gdula-Dymek Anna, Bednarska-Czerwińska Anna, Okopień Bogusław
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, PL 40-752 Katowice, Poland.
Pharmacol Rep. 2007 Sep-Oct;59(5):500-16.
Growth hormone (GH) is a polypeptide hormone, secreted by somatotropic cells of the anterior part of the hypophysis. Its application in therapy, first limited to GH deficient children, has now been widened to various other clinical conditions, not necessarily related to short stature. Clinical trials conducted in recent years have proved the safety of its administration in both children and adults. The efficacy of this form of therapy varies, according to different authors, from enthusiastic data to very critical opinions. For many pediatric diseases, such as GH deficiency or Turner syndrome, GH is regarded by many experts, despite the high costs of the therapy, as the first-line treatment. Mounting evidence suggests that GH is safe and effective also in children with chronic renal failure and cystic fibrosis. Recently, it has also been administered to adults with GH deficiency and short bowel syndrome. The aim of this paper is to summarize the current data on GH administration in modern pharmacotherapy. In this paper we have included the results of the recently published studies and discussed not commonly known indications for GH therapy, as well as its experimental administration in both children and adults.
生长激素（GH）是一种多肽激素，由垂体前叶的促生长细胞分泌。其在治疗中的应用最初仅限于生长激素缺乏的儿童，现在已扩展到各种其他临床情况，不一定与身材矮小有关。近年来进行的临床试验证明了其在儿童和成人中使用的安全性。根据不同作者的观点，这种治疗方式的疗效各不相同，从热情的数据到非常批判性的意见都有。对于许多儿科疾病，如生长激素缺乏或特纳综合征，尽管治疗费用高昂，但许多专家仍将生长激素视为一线治疗方法。越来越多的证据表明，生长激素在慢性肾功能衰竭和囊性纤维化儿童中也是安全有效的。最近，它也被用于治疗生长激素缺乏和短肠综合征的成人。本文的目的是总结现代药物治疗中生长激素应用的当前数据。在本文中，我们纳入了最近发表的研究结果，并讨论了生长激素治疗不常见的适应症，以及其在儿童和成人中的试验性应用。
