Forrester Mathias B
Epidemiology and Disease Surveillance Unit, Texas Department of State Health Services, Austin, Texas 78756, USA.
J Toxicol Environ Health A. 2007 Dec;70(24):2027-32. doi: 10.1080/15287390701601194.
Review of the literature failed to identify any information on potentially adverse ingestions of the cholesterol-lowering drug gemfibrozil (GEM) reported to poison control centers. Data from Texas poison control centers were used to describe the pattern of isolated GEM ingestions reported during 2000-2005. A total of 118 cases were identified. The mean maximum dose ingested was 2407 mg (range 300-18,000 mg) or 3.3 tablets/capsules (range 1-30 tablets/capsules). The patient was male in 55% of the cases. The most common circumstances of the exposure were unintentional therapeutic error (49%), general unintentional (34%), and suspected attempted suicide (11%). The management site was on site (84%), already at/en route to a health care facility (10%), referred to a health care facility (5%), and other (2%). The ingestion considered potentially toxic in 3% of the cases and no deaths were reported. A specific adverse clinical effect was listed for 9% of the cases, being gastrointestinal (5%), neurological (3%), or cardiovascular (1%). A specific treatment was listed for 54% of the cases, most frequently decontamination by dilution (39%) or food (15%). Potentially adverse isolated GEM ingestions reported to poison control centers generally do not involve serious medical outcomes and are successfully managed at home with a favorable outcome.
文献综述未能找到向中毒控制中心报告的有关降胆固醇药物吉非贝齐（GEM）潜在有害摄入的任何信息。德克萨斯中毒控制中心的数据被用于描述2000年至2005年期间报告的单独吉非贝齐摄入模式。共识别出118例病例。摄入的平均最大剂量为2407毫克（范围300 - 18000毫克）或3.3片/胶囊（范围1 - 30片/胶囊）。55%的病例患者为男性。最常见的暴露情况是无意的治疗错误（49%）、一般无意情况（34%）和疑似自杀未遂（11%）。处理地点为现场（84%）、已在前往医疗机构途中（10%）、转诊至医疗机构（5%）以及其他（2%）。3%的病例摄入被认为具有潜在毒性，且未报告死亡情况。9%的病例列出了特定的不良临床效应，包括胃肠道（5%）、神经（3%）或心血管（1%）。54%的病例列出了特定治疗方法，最常见的是通过稀释（39%）或食物（15%）进行去污。向中毒控制中心报告的潜在有害单独吉非贝齐摄入一般不涉及严重医疗后果，且在家中成功处理，预后良好。
