Lin Yee-Pin Kristi, Zurakowski David, Ayyala Ramesh S
Department of Ophthalmology, Tulane School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Ophthalmic Surg Lasers Imaging. 2007 Nov-Dec;38(6):471-7. doi: 10.3928/15428877-20071101-05.
To compare the safety and efficacy of fornix-based trabeculectomy with corneal valve to traditional limbal-based trabeculectomy with mitomycin C (MMC) in eyes with open-angle glaucoma.
In this retrospective, nonrandomized, comparative study, 42 eyes that underwent limbal-based trabeculectomy with MMC were compared with 32 eyes with fornix-based trabeculectomy with corneal valve with MMC. Success was defined as final intraocular pressure (IOP) of at least 20% less than preoperative IOP and between 5 and 22 mm Hg. mean IOPs were 23.5 +/- 12.2 and 11.5 +/- 5.3 mm Hg, respectively, in the limbal-based group and 24.8 +/- 11.1 and 11.7 +/- 2.5 mm Hg, respectively, in the fornix-based group (P < .001 and P = .85, respectively). The fornix-based group had significantly less hypotony (3% vs. 21%, P < .05).
Fornix-based corneal valve trabeculectomy with posterior placement of MMC sponges provides IOP control comparable to limbal-based traditional trabeculectomy, with decreased incidence of hypotony.
比较穹窿部小梁切除术联合角膜瓣与传统的角膜缘部小梁切除术联合丝裂霉素C（MMC）治疗开角型青光眼的安全性和有效性。
在这项回顾性、非随机对照研究中，将42例行角膜缘部小梁切除术联合MMC的患眼与32例行穹窿部小梁切除术联合角膜瓣及MMC的患眼进行比较。成功定义为最终眼压（IOP）比术前眼压至少降低20%，且在5至22 mmHg之间。角膜缘部组的平均眼压分别为23.5±12.2 mmHg和11.5±5.3 mmHg，穹窿部组分别为24.8±11.1 mmHg和11.7±2.5 mmHg（P分别<0.001和P = 0.85）。穹窿部组低眼压发生率显著更低（3%对21%，P<0.05）。
MMC海绵后置的穹窿部角膜瓣小梁切除术在眼压控制方面与角膜缘部传统小梁切除术相当，且低眼压发生率降低。
