Bédos J P, Rolin O, Bouanchaud D H, Pocidalo J J
Clinique de Réanimation des Maladies Infectieuses du P Vachon, INSERM U 13, Hôpital Bichat-Claude Bernard, Paris, France.
Pathol Biol (Paris). 1991 Dec;39(10):984-90.
Epidemiologic data show that the organ affinity of Streptococcus pneumoniae varies across serotypes. As a result of this heterogeneous distribution, exposure to antimicrobials is greater for serotypes 6, 14, 19 and 23. Most strains with resistance to antimicrobials are found among these four serotypes. Virulence of the various serotypes of pneumococci varies with adhesion, enzyme secretion, and resistance to phagocytosis. In a mouse model of experimental septicemia, neither the origin of strains nor the acquisition of a resistant phenotype modified virulence, which appeared as an intrinsic feature specific to each phenotype. Strains belonging to serotypes 6, 14, 19 and 23 with or without resistance to antimicrobials were only very rarely virulent in the experimental model used. As an indirect result, resistance to antimicrobials and virulence were inversely related among the strains of S. pneumoniae tested.
流行病学数据表明，肺炎链球菌的器官亲和力因血清型而异。由于这种分布不均，血清型6、14、19和23接触抗菌药物的机会更多。大多数对抗菌药物耐药的菌株都在这四种血清型中发现。肺炎球菌不同血清型的毒力因黏附、酶分泌和抗吞噬作用而有所不同。在实验性败血症小鼠模型中，菌株的来源和耐药表型的获得均未改变毒力，毒力似乎是每种表型特有的内在特征。在所用的实验模型中，属于血清型6、14、19和23的菌株，无论有无抗菌药物耐药性，都极少具有毒力。间接结果是，在所测试的肺炎链球菌菌株中，抗菌药物耐药性与毒力呈负相关。
