从新西兰褐藻Perithalia capillaris中提取的一种具有抗增殖作用的双异戊烯基醌。

An antiproliferative bis-prenylated quinone from the New Zealand brown alga Perithalia capillaris.

作者信息

Sansom Catherine E, Larsen Lesley, Perry Nigel B, Berridge Michael V, Chia Elizabeth W, Harper Jacquie L, Webb Victoria L

机构信息

TerraMarine Pharmaceuticals, New Zealand Institute for Crop & Food Research Ltd, Chemistry Department, University of Otago, Dunedin, New Zealand.

出版信息

J Nat Prod. 2007 Dec;70(12):2042-4. doi: 10.1021/np070436t. Epub 2007 Dec 1.

DOI:10.1021/np070436t

PMID:18052030

Abstract

Bioactivity-directed isolation work on the endemic New Zealand brown alga Perithalia capillaris, seeking anti-inflammatory compounds, led to a new bis-prenylated quinone ( 4). This compound inhibited superoxide production by human neutrophils in vitro (IC 50 2.1 microM), but was more potent at inhibiting proliferation of HL60 cells (IC 50 0.34 microM). Two related bis-prenylated phenols were also isolated, one known ( 2) and one new ( 5), with weaker biological activities. This report extends the examples of bis-prenylated phenols as chemotaxonomic markers for brown algae of the order Sporochnales.

摘要

针对新西兰本土褐藻毛细围丝藻开展的生物活性导向分离工作，旨在寻找抗炎化合物，从中得到了一种新的双异戊烯基醌（4）。该化合物在体外可抑制人中性粒细胞产生超氧化物（半数抑制浓度[IC50]为2.1微摩尔），但在抑制HL60细胞增殖方面更具效力（IC50为0.34微摩尔）。还分离出了两种相关的双异戊烯基酚，一种为已知化合物（2），另一种为新化合物（5），它们的生物活性较弱。本报告扩展了双异戊烯基酚作为蕨藻目褐藻化学分类学标志物的实例。