一种来自海洋褐藻带形蜈蚣藻的新型酪氨酸激酶抑制剂。

A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale.

作者信息

Wessels M, König G M, Wright A D

机构信息

Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig, Germany.

出版信息

J Nat Prod. 1999 Jun;62(6):927-30. doi: 10.1021/np990010h.

DOI:10.1021/np990010h

PMID:10395524

Abstract

From the lipophilic extract of the marine brown alga Stypopodium zonale (Dictyotaceae) the new terpenoid compound stypoquinonic acid (1) together with the known compounds taondiol (2) and atomaric acid (3) were isolated. The structures of all isolates were determined from their spectroscopic data, including 1- and 2-dimensional NMR methods. The new compound, 1, and atomaric acid (3), showed inhibition of tyrosine kinase (p56lck).

摘要

从海洋褐藻带状匍扇藻（网地藻科）的亲脂性提取物中，分离出了新的萜类化合物匍扇藻醌酸（1）以及已知化合物陶诺二醇（2）和阿托马酸（3）。所有分离物的结构均通过其光谱数据确定，包括一维和二维核磁共振方法。新化合物1和阿托马酸（3）显示出对酪氨酸激酶（p56lck）的抑制作用。